Veterinary Sciences, Free Full-Text

Canine hemangiosarcoma (HSA) is a relatively common neoplasia, occurring mainly in the skin, spleen, liver and right atrium. Despite the numerous studies investigating the treatment of canine HSA, no significant improvement in survival has been achieved in the last 20 years. Advancements in genetic and molecular profiling presented molecular similarities between canine HSA and human angiosarcoma. It could therefore serve as a valuable model for investigating new and more effective treatments in people and dogs. The most common genetic abnormalities in canine HSA have been found in the phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA) and neuroblastoma RAS viral oncogene homolog (NRAS) pathways. Mutations are also found in tumor protein p53 (TP53), phosphatase and tensin homolog (PTEN) and cyclin dependent kinase inhibitor 2A (CDKN2A). Known abnormal protein expression could be exploited to trial new target treatments that could be beneficial for both canine and human patients. Despite the high expression of vascular endothelial growth factor (VEGF) and its receptor (VEGFR), no correlation with overall survival time has ever been found. In this review, we explore the most recent developments in molecular profiling in canine HSA and discuss their possible applications in the prognosis and treatment of this fatal disease.

Introduction to Veterinary Science, 3rd Edition

Aradhya Tutorials Ada Notes Download Pdf - Colaboratory

Cypress Veterinary Clinic

PDF) Development of a Short-Term Canine Full-Thickness Skin Organ Culture Method under Serum-Free Conditions

PDF) Quantifying capture stress in free ranging European roe deer (Capreolus capreolus)

Proceedings of the XXXth Congress of the European Association of Veterinary Anatomists Cluj‐Napoca, Romania July 23–26, 2014 - 2014 - Anatomia, Histologia, Embryologia - Wiley Online Library

Veterinary Science « St. Clare's Careers

Tips To Make Burnout In Veterinary Medicine A Thing Of The Past

Veterinary Sciences An Open Access Journal from MDPI

MSU Animal & Range Sciences

Client Education on Fear Free