Nutrients, Free Full-Text
Por um escritor misterioso
Last updated 17 dezembro 2024
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The mesencephalic trigeminal nucleus (Mes5) processes oral sensory–motor information, but its role in the control of energy balance remains unexplored. Here, using fluorescent in situ hybridization, we show that the Mes5 expresses the melanocortin-4 receptor. Consistent with MC4R activation in other areas of the brain, we found that Mes5 microinjection of the MC4R agonist melanotan-II (MTII) suppresses food intake and body weight in the mouse. Furthermore, NTS POMC-projecting neurons to the Mes5 can be chemogenetically activated to drive a suppression in food intake. Taken together, these findings highlight the Mes5 as a novel target of melanocortinergic control of food intake and body weight regulation, although elucidating the endogenous role of this circuit requires future study. While we observed the sufficiency of Mes5 MC4Rs for food intake and body weight suppression, these receptors do not appear to be necessary for food intake or body weight control. Collectively, the data presented here support the functional relevance of the NTS POMC to Mes5 projection pathway as a novel circuit that can be targeted to modulate food intake and body weight.
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Whole Nutrition Infant Formula – ByHeart
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Vunerable Iso Get File - Colaboratory
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Egg Nutrition Facts and Health Benefits
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Nutrients, Free Full-Text
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MyPlate U.S. Department of Agriculture
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Food Composition Table Software - Colaboratory
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Whole Nutrition Infant Formula – ByHeart
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Nutrition in medical education: a systematic review - The Lancet Planetary Health
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Nutrients, Free Full-Text
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Impact of Varying Dosages of Fish Oil on Recovery and Soreness Following Eccentric Exercise, Nutrients
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Home Page: The American Journal of Clinical Nutrition
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Nutrients, Free Full-Text
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